Desonide Anti-Inflammatory Skin Lotion 0.05% by WatsonDesonide Lotion 0. 05% is a topical (for the skin) steroid. Desonide reduces the actions of chemicals in the body that cause inflammation, redness, and swelling. Desonide topical is used to treat the inflammation and itching caused by a number of skin conditions such as allergic reactions, eczema, and psoriasis. This medication is used to treat a variety of skin conditions (e. g., eczema, dermatitis, allergies, rash). Desonide reduces the swelling,